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National Institute of Genetics

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Publications

2024

Iida, S., Ide, S., Tamura, S., Sasai, M., Tani, T., Goto, T., Shribak, M., Maeshima, K.(2024) Orientation-Independent-DIC imaging reveals that a transient rise in depletion force contributes to mitotic chromosome condensation.
Proceedings of the National Academy of Sciences121, e2403153121.
doi:10.1073/pnas.2403153121

Hibino, K., Sakai, Y.,Tamura, S., Takagi, M., Minami, K., Shimazoe, M.A., Natsume, T., Kanemaki, M.T., Imamoto, N., Maeshima, K. (2024) Single-nucleosome imaging unveils that condensins and nucleosome-nucleosome interactions differentially constrain chromatin to organize mitotic chromosomes.
Nature Communications 15, 7152.
doi: 10.1038/s41467-024-51454-y

Semeigazin, A., Iida, S., Minami, K.,Tamura, S.,Ide, S., Higashi, K., Toyoda, A., Kurokawa, K., Maeshima, K.(2024) Behaviors of the nucleosomes with mutant histone H4s in euchromatic domains of living human cells. Histochemistry and Cell Biology
https://link.springer.com/article/10.1007/s00418-024-02293-x

Otsuka, A., Minami, K., Higashi, K., Kawaguchi, A., Tamura, S., Ide, S., Hendzel, M.J., Kurokawa, K., Maeshima, K. (2024) Chromatin organization and behavior in RAS-transformed mouse fibroblasts. Chromosoma.
https://doi.org/10.1007/s00412-024-00817-x

Iida, S., Ide, S., Tamura, S., Tani, T., Goto, T., Shribak, M., Maeshima, K. (2023) Orientation-Independent-DIC imaging reveals that a transient rise in depletion force contributes to mitotic chromosome condensation. bioRxiv BIORXIV/2023/566679
https://doi.org/10.1101/2023.11.11.566679

2023

Maeshima, K., Iida, S., Shimazoe, M.A., Tamura, S., Ide, S. (2023) Is euchromatin really open in the cell? Trends in Cell Biology. doi: 10.1016/j.tcb.2023.05.007

Smallwood, K., Watt, K. E.N., Ide, S., Baltrunaite, K., Brunswick, C., Inskeep, K., Capannari, C., Adam, M. P., Begtrup, A., Bertola, D. R., Cho, M., Demmer, L., Demo, E., Devinsky, O., Gallagher, E. R., Sacoto, M. J. G., Jech, R., Keller-Ramey, J., Keren, B., Kussmann, J., Ladda, R., Lansdon, L. A., Lunke, S., Mardy, A., McLaughlin, H., McWalters, K., Person, R., Raiti, L., Saitoh, N., Saunders, C. J., Schnur, R., Skorvanek, M., Sell, S. L., Slavotinek, A., Sullivan, B. R., Stark, Z., Symonds, J.D., Wenger, T., Weber, S., Whalen, S., White, S. M., Willaert, R., Winkelman, J., Zech, M., Zeidler, S., Maeshima, K., Stottmann, R. W., Trainor, P. A, Weaver, K. N. (2023) Variant- and tissue-specific effects underlie phenotypic heterogeneity in individuals with heterozygous variants in POLR1A. The American Journal of Human Genetics 110, 1–17.
https://doi.org/10.1016/j.ajhg.2023.03.014

Nozaki, T., Shinkai, S., Ide, S., Higashi, K., Tamura, S., Shimazoe, A. M., Nakagawa, M., Suzuki, Y., Okada, Y., Sasai, M., Onami, S., Kurokawa, K., Iida, S., *Maeshima, K. (2022) Condensed but liquid-like domain organization of active chromatin regions in living human cells. Science Advances.9, eadf1488
Doi: 10.1126/sciadv.adf1488

2022

Minami, K., Iida, S.,Maeshima, K. (2022) Chromatin organization and DNA damage. The Enzymes Volume LI: DNA damage and double strand breaks (Eds. K. Yoshikawa and F. Tamanoi). Chapter 3. A cademic Press/Elsevier.
https://doi.org/10.1016/bs.enz.2022.08.003
Free link（until 11/16）

Maeshima, K., Meshorer, E. (2022) Editorial Overview: Emerging concepts and tools in genome organization and chromatin function in eukaryotes
Current Opinion in Cell Biology, 78:102120
https://doi.org/10.1016/j.ceb.2022.102120

Maeshima, K.(2022) A phase transition for chromosome transmission when cells divide. Nature. 609, 35-36.
https://doi.org/10.1038/d41586-022-01925-3

Ide, S., Tamura, S., Maeshima, K. (2022) Chromatin behavior in living cells: lessons from single-nucleosome imaging and tracking. BioEssays. 44, 2200043.
doi: 10.1002/bies.202200043

Iida, S., Shinkai, S.,Itoh, Y., Tamura, S., Kanemaki, M.T., Onami, S., Maeshima, K. (2022) Single-nucleosome imaging reveals steady-state motion of interphase chromatin in living human cells. Science Advances. 8, eabn5626
doi: 10.1126/sciadv.abn5626

2021

Hansen, J.C., Maeshima, K., Hendzel, M.J. (2021) The solid and liquid states of chromatin. Epigenetics & Chromatin. 14, 50.
doi: 10.1186/s13072-021-00424-5

Ide, S., Sasaki, A., Kawamoto, Y., Bando, T., Sugiyama, H., Maeshima, K. (2021) Telomere-specific chromatin capture using a pyrrole–imidazole polyamide probe for the identification of proteins and non-coding RNAs. Epigenetics & Chromatin. 14, 46.
doi: 10.1186/s13072-021-00421-8

Maeshima, K., Iida, S. (2021) Loopy world of cohesin eLife 10, e71585.
doi: 10.7554/eLife.71585

Itoh, Y., Woods, E.J., Minami, K., *Maeshima, K., *Collepardo-Guevara, R. (2021) Liquid-like chromatin in the cell: What can we learn from imaging and computational modeling? Current Opinion in Structural Biology. 71, 123–135
doi: 10.1016/j.sbi.2021.06.004

Hoencamp, C., Dudchenko, O., Elbatsh, A. M.O., Brahmachari, S., Raaijmakers, J. A., van Schaik, T., Cacciatore, Á. S., Contessoto, V., van Heesbeen, R. G.H.P., van den Broek, B., Mhaskar, A. N., Teunissen, H., St Hilaire, B. G., Weisz, D., Omer, A. D., Pham, M., Colaric, Z., Yang, Z., Rao, S. S.P., Mitra, N., Lui, C., Yao, W., Khan, R., Moroz, L. L., Kohn, A., St. Leger, J., Mena, A., Holcroft, K., Gambetta, M. C., Lim, F., Farley, E., Stein, N., Haddad, A., Chauss, D., Mutlu, A. S., Wang, M. C., Young, N. D., Hildebrandt, E., Cheng, H. H., Knight, C. J., Burnham, T. L.U., Hovel, K. A., Beel, A. J., Mattei, P.-J., Kornberg, R. D., Warren, W. C., Cary, G., Gómez-Skarmeta, J. L., Hinman, V., Lindblad-Toh, K., di Palma, F., Maeshima, K., Multani, A. S., Pathak, S., Nel-Themaat, L., Behringer, R. R., Kaur, P., Medema, R. H., van Steensel, B., de Wit, E., Onuchic, J. N., Di Pierro, M., Lieberman-Aiden, E., Rowland, B. D. (2021) 3D genomics across the tree of life reveals condensin II as a determinant of architecture type. Science372, 984-989.
https://science.sciencemag.org/content/372/6545/984
doi:10.1126/science.abe2218

Maeshima, K.(2021) New door to understanding transcription, open with caution. In “Voices”, Molecular Cell,81, 1581-1582
https://doi.org/ 10.1016/j.molcel.2021.03.046

Maeshima, K., Iida, S., Tamura, S. (2021) Physical nature of chromatin in the nucleus.
Cold Spring Harbor Perspectives in Biology. a040675.
doi:10.1101/cshperpsect.a040675
Cover Art

Itoh, Y., Iida, S., Tamura, S., Nagashima, R., Shiraki, K., Goto, T., Hibino, K., Ide, S., Maeshima, K. (2021) 1,6-hexanediol rapidly immobilizes and condenses chromatin in living human cells. Life Science Alliance. 4, e20200100
https://www.life-science-alliance.org/content/4/4/e202001005

2020

Ide, T., Ochi, H.,Imai, R., Maeshima, K. (2020) Transcriptional suppression of ribosomal DNA with phase separation. Science Advances. 6, eabb5953

Matsuyama, S., Maeshima, K., Shimura, M. (2020) Imaging intracellular elements and structure by synchrotron X-ray with focusing system. Journal of Analytical Atomic Spectrometry. 35, 1279-1294.
https://doi.org/10.1039/D0JA00128G

Maeshima, K., Tamura, S., Hansen, J.C., Itoh, Y. (2020) Fluid-like chromatin: toward understanding the real chromatin organization present in the cell.
Current Opinion in Cell Biology. 64, 77-89.
https://doi.org/10.1016/j.ceb.2020.02.016

Ashwin, S.S., Maeshima, K., Sasai, M. (2020) Heterogeneous fluid-like movements of chromatin and their implications to transcription. Biophysical Reviews. 12, 461–468.
DOI: 10.1007/s12551-020-00675-8

Babokhov, M., Hibino, K., Ito, Y., Maeshima, K. (2020) Local chromatin motion and transcription.Journal of Molecular Biology. 432, 694-700.
https://doi.org/10.1016/j.jmb.2019.10.018

2019

Marie Anne O’Donnell (2019) Kazuhiro Maeshima : Excitement under the microscope (Interviewed by JCB as "People & Ideas”)
Journal of Cell Biology218, 3529–3530.
DOI: https://doi.org/10.1083/jcb.201910088

Ashwin, S.S., Nozaki, T., Maeshima, K., Sasai, M. (2019) Organization of fast and slow chromatin revealed by single-nucleosome dynamics.
Proc Natl Acad Sci USA. 116, 19939-19944
https://doi.org/10.1073/pnas.1907342116

Prieto, E.I., Maeshima, K. (2019) Dynamic chromatin organization in the cell. Essays in Biochemistry 63, 133-145.
doi: 10.1042/EBC20180054

Maeshima, K., Ide, S., Babokhov, M. (2019) Dynamic chromatin organization without the 30-nm fiber. Current Opinion in Cell Biology. 58, 95–104
doi: 10.1016/j.ceb.2019.02.003

Nagashima, R., Hibino, K., Ashwin, S.S., Babokhov, M., Fujishiro, S., Imai, R., Nozaki, T., Tamura, S., Tani, T., Kimura, H., Shribak, M., Kanemaki, M.T., Sasai, M., Maeshima, K. (2019) Single nucleosome imaging reveals loose genome chromatin networks via active RNA polymerase II. Journal of Cell Biology. 218, 1511-1530
doi: 10.1083/jcb.201811090
Press release
Spotlight

2018

Kazuhiro Maeshima (2018) How small numbers of long genomic DNA are stored in cells. Minorities and Small Numbers from Molecules to Organisms in Biology (Editors Takeharu Nagai and Yuichi Togashi), Springer Nature Singapore Pte Ltd.. Chapter 8, 53-58.
https://doi.org/10.1007/978-981-13-2083-5_8

Maeshima, K., Tamura, S., Shimamoto, Y. (2018) Chromatin as a nuclear spring. Biophysics and Physicobiology. 15, 189-195.
doi: 10.2142/biophysico.15.0_189
https://www.jstage.jst.go.jp/article/biophysico/15/0/15_189/_article/-char/en

Maeshima, K., Hibino, K., Hudson, D.F. (2018) Condensins under the　microscope. Journal of Cell Biology. 217, 2229–2231
doi: 10.1083/jcb.201804078

Maeshima, K., Matsuda, T., Shindo, Y., Imamura, H., Tamura, S., Imai, R., Kawakami, S., Nagashima, R., Soga, T., Noji, H., Oka, K., Nagai, T. (2018) A transient rise in free Mg2+ ions coupled with ATP reduction promotes mitotic chromosome condensation. Current Biology. 28, 444-451
http://www.cell.com/current-biology/fulltext/S0960-9822(17)31668-8
Press release
Dispatch

Hansen, J.C., Connolly, M., McDonald, C.J., Pan, A., Pryamkova, A., Ray, K., Seidel, E., Tamura,S., Rogge, R., Maeshima, K. (2018) The 10-nm Chromatin Fiber and its Relationship to Interphase Chromosome Organization.
Biochemical Society Transactions. 46, 67-76
DOI: 10.1042/BST20170101

2017

Nozaki, T., Hudson, F. D., Tamura, S., Maeshima, K. (2017) Dynamic chromatin folding in the cell. Nuclear Architecture and Dynamics (Editors Christophe Lavelle and Jean-Marc Victor). Chapter 4, 101-122
https://doi.org/10.1016/B978-0-12-803480-4.00004-1

Imai, R., Nozaki, T., Tani, T., Kaizu, K., Hibino, K., Ide, S., Tamura, S., Takahashi, K., Shribak, M., and Maeshima, K. (2017) Density imaging of heterochromatin in live cells using orientation-independent-DIC microscopy.
Molecular Biology of the Cell. 28, 3349-3359
http://www.molbiolcell.org/content/28/23/3349.full

Nozaki, T., Imai, R., Tanbo, M., Nagashima, R., Tamura, S., Tani, T., Joti, Y., Tomita, M., Hibino, K., Wendt, K.S., Okada, Y., Nagai, T., Maeshima, K. (2017) Dynamic organization of chromatin domains revealed by super-resolution live-cell imaging. Molecular Cell. 67, 282-293
http://dx.doi.org/10.1016/j.molcel.2017.06.018

Shimamoto, Y., Tamura, S., Masumoto, H., Maeshima, K. (2017) Nucleosome-nucleosome interactions via histone tails and linker DNA regulate nuclear rigidity. Molecular Biology of the Cell. 28, 1580-1589
http://www.molbiolcell.org/content/28/11/1580.full

Shinkai, S., Nozaki, T., Maeshima, K., Togashi, Y. (2017) Bridging the dynamics and organization of chromatin domains by mathematical modeling. Nucleus
http://dx.doi.org/10.1080/19491034.2017.1313937

Hibino, K., Kaizu, K., Takahashi, K., Maeshima, K. (2017) Combination approach of live-cell imaging and computational modeling toward further comprehensive understanding genome, chromatin and epigenetics. Epigenetics and Systems Biology (Editor Leonie Ringrose) Chapter 11, 225-238.
Doi.org/10.1016/B978-0-12-803075-2.00011-8

2016

Shinkai, S., Nozaki, T., Maeshima, K., Togashi, Y. (2016) Dynamic nucleosome movement tells Structural information of topological chromatin domains in human cells. PLOS Computational Biology 12: e1005136.
Doi: 10.1371/ journal.pcbi.1005136
Cover image

Kawamoto, Y., Sasaki, A., Chandrana, A., Hashiya, K.,Ide, S., Bando, T., Maeshima, K., Sugiyama, H. (2016) Targeting 24 bp within Telomere Repeat Sequences with Tandem Tetramer Pyrrole– Imidazole Polyamide Probes. Journal of the American Chemical Society 138, 14100-14107.
Doi: 10.1021/jacs.6b09023

Chen, C., Hwa Lim, H., Shi, J., Tamura, S., Maeshima, K., Surana, U., and Gan, L. (2016) Budding yeast chromatin is dispersed in a crowded nucleoplasm. Molecular Biology of the Cell 27, 3357-3368.
Doi: 10.1091/mbc.E16-07-0506

Sasaki, A., Ide, I., Kawamoto, Y., Bando, T., Murata, Y., Shimura, M., Yamada, K., Hirata, A., Nokihara, K., Hirata, T., Sugiyama, H., Maeshima, K. (2016) Telomere Visualization in Tissue Sections Using Pyrrole-Imidazole Polyamide Probes. Scientific Reports 6, 29261.
Doi: 10.1038/srep29261

Imai, R., Komeda, S., Shimura, M., Tamura, S., Matsuyama, S., Nishimura, K., Rogge, R., Matsunaga, A., Hiratani, I., Takata, H., Uemura, M., Iida, Y., Yoshikawa, Y., Hansen, JC., Yamauchi, K., Kanemaki, MT, Maeshima, K. (2016) Chromatin folding and DNA replication inhibition mediated by a highly antitumor-active tetrazolato-bridged dinuclear platinum(II) complex. Scientific Report 6, 24712.
Doi: 10.1038/srep24712

Maeshima, K., Rogge, R., Tamura, S., Joti, Y., Hikima, T., Szerlong, H., Krause, C., Herman, J., DeLuca, J., Ishikawa, T., Hansen, J.C. (2016) Nucleosomal arrays self-assemble into supramolecular globular structures lacking 30-nm fibers. EMBO J. 35, 1013-1149.
Doi: 10.15252/embj.201592660

Maeshima, K., Ide, S., Hibino, K., Sasai, M. (2016) Liquid-like behavior of chromatin. Current Opinion in Genetics and Development 37, 36–45.
Doi: 10.1016/j.gde.2015.11.006

2015

Liang, Z., Zickler, D., Prentiss, M., Chang. F.S., Witz, G., Maeshima, K., Kleckner, N. (2015) Chromosomes progress to metaphase in multiple discrete steps via global compaction/expansion (stress) cycles. Cell 161, 1124–1137.
http://dx.doi.org/ 10.1016/j.cell.2015.04.030

Kawamoto, Y., Sasaki, A., Hashiya, K., Ide, S., Bando, T., Maeshima, K., Sugiyama, H. (2015) Tandem trimer pyrrole–imidazole polyamide probes targeting 18 base pairs in human telomere sequences. Chemical Science 6, 2307-2312.
Doi: 10.1039/c4sc03755c

Maeshima, K. Kaizu, K., Tamura, S., Nozaki, T., Kokubo, T., Takahashi, K. (2015) The physical size of transcription factors is key to transcriptional regulation in the chromatin domains. Journal of Physics: condensed matter 27, 064116 (10pp).
Doi:10.1088/0953-8984-27/6/064116
Lab Talk

2014

Maeshima, K., Nishino, Y., Joti, Y. (2014) Irregular organization in the human chromosomes revealed by X-ray scattering. SPring-8 Research Frontiers2013 32-33.

Maeshima, K., Imai, R., Hikima, T., Joti, Y. (2014) Chromatin Structures Revealed by Small-angle Xray Scattering Analysis and Computational Modeling. Methods 70, 154-161.
Doi: 10.1016/j.ymeth.2014.08.008

Hirata, A., Nokihara, K., Kawamoto, Y., Bando, T., Sasaki, A., Ide ,S., Maeshima, K., Kasama, T., Sugiyama, H. (2014) Structual Evaluation of Tandem, Hairpin Pyrrole-Imidazole Polyamides Recognizing Human Telomeres. Journal of American Chemical Society 136, 11546-11554.
DOI : 10.1021/ja506058e

Maeshima, K., Imai, R., Tamura, S., Nozaki,T. (2014) Chromatin as dynamic 10-nm fibers. Chromosoma 123, 225-237.
Doi: 10.1007/s00412-014-0460-2

Nozaki, T., Imai, R., Tamura, S., Maeshima, K. (2014) Single nucleosome imaging in living human cells (Technical note,cover image ).
Cytologia 79(1) 1-2.
Doi: 10.1508/cytologia.79.1.1

Kuga, T., Nie, H., Kazami, T., Satoh, M., Matsushita, K., Nomura, F., Maeshima, K., Nakayama, Y., Tomonaga, T. (2014) Lamin B2 prevents chromosome instability by ensuring proper mitotic chromosome segregation. Oncogenesis 3, e94.
Doi: 10.1038/oncsis.2014.6

Maeshima, K., Funakoshi, T., Imamoto, N. (2014) Cell-fusion method to visualize interphase nuclear pore (NPC) formation. Methods in Cell Biology 122, 239-254.

2013

Kawamoto, Y., Bando, T., Kamada, F., Li, Y., Hashiya, K., Maeshima, K., Sugiyama, H. (2013) Development of a New Method for Synthesis of Tandem Hairpin Pyrrole-Imidazole Polyamide Probes Targeting Human Telomeres. Journal of the American Chemical Society 135, 16468-16477.
DoiI: 10.1021/ja406737n

Takata, H., Hanafusa, T., Mori, T., Shimura, M., Iida,Y., Ishikawa, K., Yoshikawa, K., Yoshikawa, Y., Maeshima, K. (2013) Chromatin compaction protects genomic DNA from radiation damage. PLOS ONE 8, e75622.
Doi: 10.1371/journal.pone.0075622

Nozaki, T., Kaizu, K., Pack, C.G., Tamura, S., Tani, T., Hihara, S., Nagai, T., Takahashi, K., Maeshima, K. (2013) Flexible and dynamic nucleosome fiber in living mammalian cells. Nucleus 4, 349-356.
Doi: 10.4161/nucl.26053.

Shang, W. H., Hori, T., Martins, N. M., Toyoda, A., Misu, S., Monma, N., Hiratani, I., Maeshima, K., Ikeo, K., Fujiyama, A., Kimura, H., Earnshaw, W.C., Fukagawa, T. (2013) Chromosome Engineering Allows the Efficient Isolation of VertebrateNeocentromeres. Dev.Cell 24, 635-648.

Takata, H., Matsunaga, S., Maeshima, K. (2013) The organisation of genomic DNA in mitotic chromosomes: a novel view. In Greilhuber, J., Leitch, I., Wendel, J., Dolezel, J.(Eds.), Plant Genome Diversity 2, (pp: 33-34), Springer Verlag, Germany

2012

Hihara, S., Pack, C. G., Kaizu, K., Tani, T., Hanafusa, T., Nozaki, T., Takemoto, S., Yoshimi, T., Yokota, H., Imamoto, N., Sako, Y., Kinjo, M., Takahashi, K., Nagai, T.,Maeshima, K. (2012) Local Nucleosome Dynamics Facilitate Chromatin Accessibility in Living Mammalian Cells.
Cell Reports 2, 1645-1656.
Web

Joti, Y., Hikima, T., Nishino, Y., Kamada F., Hihara S., Takata H., Ishikawa, T., Maeshima, K. (2012) Chromosomes without a 30-nm chromatin fiber. Nucleus 3, 404-410.
Web

Takata, H., Nishijima, H., Maeshima, K., Shibahara, K. (2012) The integrator complex is required for integrity of Cajal bodies. J Cell Sci. 125, 166-175.

Nishino, Y., Eltsov, M., Joti, Y., Ito, K., Takata, H., Takahashi, Y., Hihara, S., Frangakis, A.S., Imamoto, N., Ishikawa, T., Maeshima, K. (2012) Human mitotic chromosomes consist predominantly of irregularly folded nucleosome fibres without a 30-nm chromatin structure. EMBO J. 31, 1644-53.

2011

Takata, H., Maeshima, K. (2011) Irregular folding of nucleosomes in the cell: comment on "Cracking the chromatin code: precise rule of nucleosome positioning" by Edward N. Trifonov. Phys Life Rev 8, 51-52; discussion 69-72

Maeshima, K., Iino, H., Hihara, S., Imamoto, N. (2011) Nuclear size, nuclear pore number and cell cycle. Nucleus 2, 113-118.
Web

2010

Maeshima, K., Hihara, S., Takata, H. (2010 (published in 2011) ) New insight into the mitotic chromosome structure: irregular folding of nucleosome fibers without 30-nm chromatin structure. Cold Spring Harb Symp Quant Biol. 75, 439-444.

Maeshima, K., Iino, H., Hihara, S., Funakoshi, T., Watanabe, A., Nishimura, M., Nakatomi, R., Yahata, K., Imamoto, F., Hashikawa, T., et al. (2010) Nuclear pore formation but not nuclear growth is governed by cyclin-dependent kinases (Cdks) during interphase. Nat Struct Mol Biol. 17, 1065-1071.

Matsuyama, S., Shimura, M., Fujii, M., Maeshima, K., Yumoto, H., Mimura, H., Sano, Y., Yabashi, M., Nishino, Y., Tamasaku, K., et al. (2010) Elemental mapping of frozen hydrated cells with cryo-scanning X-ray fluorescence microscopy.X-Ray Spectrometry 39, 260-266.

Iino, H., Maeshima, K., Nakatomi, R., Kose, S., Hashikawa, T., Tachibana, T., Imamoto, N. (2010) Live imaging system for visualizing nuclear pore complex (NPC) formation during interphase in mammalian cells. Genes Cells 15, 647-660.

Maeshima, K., Hihara, S., Eltsov, M. (2010) Chromatin structure: does the 30-nm fibre exist in vivo? Curr Opin Cell Biol 22, 291-297.

2009

Takemoto, A.,Maeshima, K., Ikehara, T., Yamaguchi, K., Murayama, A., Imamura, S., Imamoto, N., Yokoyama, S., Hirano, T., Watanabe, Y., et al. (2009) The chromosomal association of condensin II is regulated by a noncatalytic function of PP2A. Nat Struct Mol Biol. 16, 1302-1308.

Nishino, Y., Takahashi, Y., Imamoto, N., Ishikawa, T., Maeshima, K. (2009) Three-dimensional visualization of a human chromosome using coherent X-ray diffraction. Phys Rev Lett. 102, 018101.

2008

Tahara, K., Takagi, M., Ohsugi, M., Sone, T., Nishiumi, F., Maeshima, K., Horiuchi, Y., Tokai-Nishizumi, N., Imamoto, F., Yamamoto, T., et al. (2008) Importin-beta and the small guanosine triphosphatase Ran mediate chromosome loading of the human chromokinesin Kid.
J Cell Biol. 180, 493-506.

Eltsov, M., Maclellan, K. M., Maeshima, K., Frangakis, A. S., and Dubochet, J. (2008) Analysis of cryo-electron microscopy images does not support the existence of 30-nm chromatin fibers in mitotic chromosomes in situ. Proc Natl Acad Sci USA 105, 19732-19737.
Web

Iwai, Y., Ikeda, T., Kojima, T. M., Yamazaki, Y.,Maeshima, K., Imamoto, N., Kobayashi, T., Nebiki, T., Narusawa, T., and Pokhil, G.-P. (2008) Ion irradiation in liquid of μm3 region for cell surgery. Applied Physics Letters 92, 23509 (23503 pages).

Maeshima, K., Eltsov, M. (2008) Packaging the genome : the structure of mitotic chromosomes. J Biochem. 143, 145-53.
Web

Wendt, K.S., Yoshida, K., Itoh, T., Bando, M., Koch, B., Schirghuber, E., Tsutsumi, S., Nagae, G., Ishihara, K., Mishiro, T., et al. (2008) Cohesin mediates transcriptional insulation by CCCTC-binding factor. Nature 451, 796-801.

2007

Funakoshi, T.,Maeshima, K., Yahata, K., Sugano, S., Imamoto, F., Imamoto, N. (2007) Two distinct human POM121 genes: requirement for the formation of nuclear pore complexes. FEBS Lett. 581, 4910-4916.

Yahata, K., Maeshima, K., Sone, T., Ando, T., Okabe, M., Imamoto, N., Imamoto, F. (2007) cHS4 insulator-mediated alleviation of promoter interference during cell-based expression of tandemly associated transgenes. J Mol Biol. 374, 580-590.

2006

Maeshima, K., Yahata, K., Sasaki, Y., Nakatomi, R., Tachibana, T., Hashikawa, T., Imamoto, F., Imamoto, N. (2006) Cell-cycle-dependent dynamics of nuclear pores: pore-free islands and lamins. J Cell Sci. 119, 4442-4451.
Web

2005

Maeshima, K., Eltsov, M., Laemmli, U. K. (2005) Chromosome structure: improved immunolabeling for electron microscopy. Chromosoma 114, 365-375.

2003

Maeshima, K., Laemmli, U. K. (2003) A two-step scaffolding model for mitotic chromosome assembly. Dev Cell 4, 467-480.

2001

Maeshima, K., Janssen, S., Laemmli, U.K. (2001) Specific targeting of insect and vertebrate telomeres with pyrrole and imidazole polyamides. EMBO J . 20, 3218-3228.

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